New Tests Could Turn Tide Against Coronavirus – If They Work

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Spain wanted some new rapid coronavirus tests so badly that it bought ones that didn’t work. So did the Czech Republic. The U.K. snapped up millions of them as well, even before scientists have established their accuracy.

Why the frenzy? Countries desperate to curb the pandemic need a clearer picture of the virus and its spread. They’re willing to make a big bet on new testing approaches that look more broadly for signs of infection than existing diagnostics. The stakes are enormous as economies around the globe grind to a halt and the death tally keeps climbing.

“They will be cheaper, easier to use and could be widely deployable,” said Catharina Boehme, chief executive officer of the Foundation for Innovative New Diagnostics in Geneva, a nonprofit group that will evaluate the new tests in coming weeks. But “there is a lot of uncertainty still about the performance of these tests.”

Until now, the only way to check whether someone had Covid-19 was to employ a labor- and resource-intensive process that detects the coronavirus’s genetic material in a person’s nose or throat sample. While highly accurate, this so-called molecular testing has drawbacks, including the short supply of key components.

The tests also run on complex machinery that require skilled technicians. The resulting bottlenecks have stymied attempts for wide-scale testing, and the tragic consequences are playing out in Milan, New York, Madrid and other hotspots around the world.

By contrast, the rapid diagnostics can be as simple as a home-pregnancy test, delivering results in less than 15 minutes, if they can be shown to work. Their underlying technology is sound, too, used widely for years to test people for influenza, HIV and Zika. The only reason it’s taken this long for them to become available is that developers had to first get their hands on patients’ blood samples to study how they reacted to the coronavirus, and then develop diagnostics that recognize the response.

The new tests come in two varieties. One hunts for so-called antigens — substances that induce an immune response such as the spikes that protrude from the coronavirus’s outer shell — in nose and throat samples. Because they are fast and simple, they are well-suited for drive-through testing centers, doctor’s offices or even homes.

The second type looks for antibodies, which a patient’s body produces in reaction to the viral attack. These tests should tell people if they’ve already beaten Covid-19, even if they never had symptoms or mistook their illness for the flu.

That ability could be a powerful way for policymakers to determine how widely the coronavirus has spread, informing decisions about when to reopen parts of the economy and who is best-suited to get back to work. In hospitals especially, putting doctors and nurses who are not contagious and presumably immune on the front lines could be crucial.

The tests could also be used over time to see how long Covid-19 immunity lasts, since experts are currently relying on past experience with outbreaks like severe acute respiratory syndrome, or SARS, as a guide, the European Centre for Disease Prevention and Control said in a recent risk assessment.

Many governments have decided they can’t wait. The U.K. has stocked up on more than 4 million finger-prick antibody blood tests that could be made available on Amazon.com Inc. and in pharmacies.

Spain bought thousands of antigen tests from a Chinese supplier, only to find out that they’re frequently saying people don’t have the coronavirus when they do. The Czech Republic also found tests it purchased from China to be less reliable than planned, while leaders in neighboring Slovakia have been critical of the kits.

“Until we have independently validated tests, governments shouldn’t be rushing in to buy millions of them,” said Rosanna Peeling, director of the International Diagnostics Centre at the London School of Hygiene and Tropical Medicine.

For all their potential upside, the new diagnostics may never be as accurate as molecular testing. A patient might test positive for Covid-19 because he developed antibodies against a different coronavirus, such as one that causes the common cold, according to Peeling.

Another risk is simply timing. The body needs about a week to build up enough antibodies to make them detectable — and that process can take even longer in older people or those whose immune system doesn’t work so well.

“If you start to feel symptoms, take the blood test and it comes up negative, are you really negative or have the antibodies just not reached the detectable level for the kit?” said Andrew Pekosz, vice chair of the department of molecular microbiology and immunology at Johns Hopkins University.

More than 100 of the antibody and antigen tests have already been made available to health systems.

Boehme’s organization, known by its acronym FIND, plans to publish findings in coming weeks on a comparison between the performance of these tests against that of their older molecular counterparts. Despite the drawbacks, she says their role in assessing the pandemic could be huge.

“Because right now, let’s face it, we’ve lost track,” Boehme said.

(c) 2020, Bloomberg · Tim Loh  

{Matzav.com}

6 COMMENTS

  1. Why bother? It’ll all be over by Chol Hamoed, as President Trump said in his press conference this week, because by then יתמו חטאים מן הארץ ורשעים עוד אינם – the coronas, or most coronas, will be eradicated from the earth and all the man-made panic and hype can be stopped and ברכי נפשי את ה’ הללוקה.

    • – There’s corona virus for which you need facial masks. – media hype for sheeple
      – And there are coronas for which you need armored vests. – President Trump for those who are awake

  2. How is it that only those who are not contaminated with fake news in general understand that this, as they say, “whole virus thing doesn’t make sense, although many have died, the lockups, the symptoms, the alarm, etc. is illogical.”

    My answer to them is: Precisely BECAUSE you don’t listen to or read fake news is what gives you a clear mind to the current situation. Broadminded people like you should be a rav and the public should go to you with their problems.

  3. Didn’t President Trump say that by “Easter” the coronavirus will be over and after that it’ll go back to it’s common name “the flu”?

  4. Why? The carnovavirus has a lot of benefits. It stopped the deaths of bronchitis, flu, pneumonia, heart attacks, old age, injuries and other sicknesses.

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